{"id":12041,"date":"2017-04-05T14:13:13","date_gmt":"2017-04-05T13:13:13","guid":{"rendered":"https:\/\/nationalwire.com.ng\/?p=12041"},"modified":"2017-04-05T14:13:13","modified_gmt":"2017-04-05T13:13:13","slug":"new-drug-shows-promise-for-sickle-cell-disease","status":"publish","type":"post","link":"https:\/\/nationalwire.com.ng\/sub\/new-drug-shows-promise-for-sickle-cell-disease\/","title":{"rendered":"New drug shows promise for sickle cell disease"},"content":{"rendered":"

A new drug combination\u2014 tetrahydrouridine (THU) and decitabine \u2014 shows great promise in the treatment of sickle cell disease (SCD). Results from a phase 1\/2 clinical trial suggest this novel oral therapy was well tolerated and produced the desired effect on red blood cells by increasing fetal hemoglobin (HbF) levels twofold.<\/span><\/p>\n

\u201cWe\u2019ve known the molecular basis for this disease for decades, and now we finally have a rational, molecular-targeted therapy that addresses not just one or two symptoms of the disease, but the root cause of the disease,\u201d says Yogen Saunthararajah, MD, a hematology expert and researcher at Cleveland Clinic. \u201cThis therapy can in principle address all the symptoms, all the complications sickle cell disease, so it\u2019s very exciting.\u201d<\/span><\/p>\n

Dr. Saunthararajah is co-author on the study which was presented at the 2016 American Society of Hematology Annual Meeting in San Diego.<\/span><\/p>

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Advertisement<\/div>\r\n\t\t\t\t\t\t\t<\/a>\r\n \r\n\t\t\t\t\t\t\t<\/div>\n

Despite longstanding knowledge about this devastating disease, effective treatments for SCD have remained elusive. Patients still contend with clinically significant complications and risk of early death despite the standard of care, hydroxyurea. The new regimen is a non-cytotoxic, normal stem-cell-sparing, rationally targeted approach to disease modification.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

A new drug combination\u2014 tetrahydrouridine (THU) and decitabine \u2014 shows great promise in the treatment of sickle cell disease (SCD). Results from a phase 1\/2 clinical trial suggest this novel oral therapy was well tolerated and produced the desired effect on red blood cells by increasing fetal hemoglobin (HbF) levels twofold. \u201cWe\u2019ve known the molecular …<\/p>\n","protected":false},"author":11,"featured_media":10239,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_exactmetrics_skip_tracking":false,"_exactmetrics_sitenote_active":false,"_exactmetrics_sitenote_note":"","_exactmetrics_sitenote_category":0,"footnotes":""},"categories":[17],"tags":[1707],"coauthors":[2392,2393],"class_list":["post-12041","post","type-post","status-publish","format-standard","has-post-thumbnail","","category-news","tag-drugs"],"yoast_head":"\nNew drug shows promise for sickle cell disease - National Wire<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/nationalwire.com.ng\/sub\/new-drug-shows-promise-for-sickle-cell-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New drug shows promise for sickle cell disease - National Wire\" \/>\n<meta property=\"og:description\" content=\"A new drug combination\u2014 tetrahydrouridine (THU) and decitabine \u2014 shows great promise in the treatment of sickle cell disease (SCD). 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